The global healthcare sector is experiencing a revolutionary shift in autoimmune disease management, with IgG4-related diseases (IgG4-RD) at the forefront of therapeutic innovation. This complex multisystem disorder, distinguished by characteristic histopathological features and elevated IgG4 levels, has emerged as a compelling target for next-generation pharmaceutical interventions. The Clinical Complexity of IgG4-Related Diseases IgG4-related diseases represent Read.